… -sea sponge Discodermia, which is immunosuppressive and cytotoxic, (Longley 1991) has potent antiproliferative activity due to its ability, to stabilize microtubules, (Haar et al. 1996; and Kowalski et al. 1997). Novartis licensed it as a cancer treatment,
§ Halichondrin B, isolated from the Japanese sponge Halichondria okadai, for melanoma and leukemia,
§ Isogranulatimide, derived from a Brazilian tunicate, is a G2 checkpoint inhibitor that is shown to kill p53-tumor cells. It is also easy to synthesize which allows researchers to make analogues (Roberge et al. 1998; Berlinck et al. 1998),
§ Debromohymenialdisine (DBH), one of several constituents of the common Palauan shallow …
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